diff --git a/ChangeLog.md b/ChangeLog.md
index 4d2b8ef7c989e..fbfb3bd320ca8 100644
--- a/ChangeLog.md
+++ b/ChangeLog.md
@@ -20,6 +20,8 @@ See docs/process.md for more on how version tagging works.
 
 4.0.20 (in development)
 -----------------------
+- Added new `emscripten_queue_microtask()` API to call the JS `queueMicrotask()`
+  function. (#25741)
 - Embind now requires C++17 or newer. See #24850.
 
 4.0.19 - 11/04/25
diff --git a/src/lib/libhtml5.js b/src/lib/libhtml5.js
index 6c28e9b5471f7..a0f7524b02e04 100644
--- a/src/lib/libhtml5.js
+++ b/src/lib/libhtml5.js
@@ -2335,6 +2335,15 @@ var LibraryHTML5 = {
     return requestAnimationFrame(tick);
   },
 
+  emscripten_queue_microtask__deps: ['$callUserCallback'],
+  emscripten_queue_microtask: (cb, userData) => {
+    {{{ runtimeKeepalivePush(); }}}
+    return queueMicrotask(() => {
+      {{{ runtimeKeepalivePop(); }}}
+      callUserCallback(() => {{{ makeDynCall('vp', 'cb') }}}(userData));
+    });
+  },
+
   emscripten_get_device_pixel_ratio__proxy: 'sync',
   emscripten_get_device_pixel_ratio: () => {
 #if ENVIRONMENT_MAY_BE_NODE || ENVIRONMENT_MAY_BE_SHELL
diff --git a/src/lib/libsigs.js b/src/lib/libsigs.js
index e2b5f43371de6..ceaa7c207f1e2 100644
--- a/src/lib/libsigs.js
+++ b/src/lib/libsigs.js
@@ -731,6 +731,7 @@ sigs = {
   emscripten_promise_race__sig: 'ppp',
   emscripten_promise_resolve__sig: 'vpip',
   emscripten_promise_then__sig: 'ppppp',
+  emscripten_queue_microtask__sig: 'vpp',
   emscripten_random__sig: 'f',
   emscripten_request_animation_frame__sig: 'ipp',
   emscripten_request_animation_frame_loop__sig: 'vpp',
diff --git a/system/include/emscripten/eventloop.h b/system/include/emscripten/eventloop.h
index 4f706f9acf63b..67a413d0835a0 100644
--- a/system/include/emscripten/eventloop.h
+++ b/system/include/emscripten/eventloop.h
@@ -26,6 +26,8 @@ void emscripten_set_immediate_loop(bool (*cb)(void *user_data), void *user_data)
 int emscripten_set_interval(void (*cb)(void *user_data) __attribute__((nonnull)), double interval_ms, void *user_data);
 void emscripten_clear_interval(int id);
 
+void emscripten_queue_microtask(void (*cb)(void *userData), void *userData);
+
 void emscripten_runtime_keepalive_push(void);
 void emscripten_runtime_keepalive_pop(void);
 bool emscripten_runtime_keepalive_check(void);
diff --git a/test/emscripten_queue_microtask.c b/test/emscripten_queue_microtask.c
new file mode 100644
index 0000000000000..8aafa95572d5f
--- /dev/null
+++ b/test/emscripten_queue_microtask.c
@@ -0,0 +1,25 @@
+/*
+ * Copyright 2025 The Emscripten Authors.  All rights reserved.
+ * Emscripten is available under two separate licenses, the MIT license and the
+ * University of Illinois/NCSA Open Source License.  Both these licenses can be
+ * found in the LICENSE file.
+ */
+
+// Test emscripten_queue_microtask() behavior
+
+#include <stdio.h>
+#include <assert.h>
+#include <emscripten.h>
+#include <emscripten/eventloop.h>
+
+void cb(void *userData) {
+  printf("cb\n");
+  assert(userData == (void*)42);
+  emscripten_force_exit(0);
+}
+
+int main() {
+  emscripten_queue_microtask(cb, (void*)42);
+  emscripten_exit_with_live_runtime();
+  return 99; // We won't reach here, but return non-zero value to guard against refactors that might exit() with this value.
+}
diff --git a/test/test_browser.py b/test/test_browser.py
index 43ca990a7d1f1..f7ad76d17156a 100644
--- a/test/test_browser.py
+++ b/test/test_browser.py
@@ -5024,6 +5024,13 @@ def test_emscripten_request_animation_frame_loop(self):
   def test_request_animation_frame(self):
     self.btest_exit('test_request_animation_frame.c')
 
+  @parameterized({
+    '': ([],),
+    'proxy_to_pthread': (['-pthread', '-sPROXY_TO_PTHREAD'],),
+  })
+  def test_emscripten_queue_microtask(self, flags):
+    self.btest_exit('emscripten_queue_microtask.c', cflags=cflags)
+
   @requires_shared_array_buffer
   def test_emscripten_set_timeout(self):
     self.btest_exit('emscripten_set_timeout.c', cflags=['-pthread', '-sPROXY_TO_PTHREAD'])