diff --git a/pandas/tests/io/parser/common/test_file_buffer_url.py b/pandas/tests/io/parser/common/test_file_buffer_url.py
index cef57318195ec..2777714dec8b2 100644
--- a/pandas/tests/io/parser/common/test_file_buffer_url.py
+++ b/pandas/tests/io/parser/common/test_file_buffer_url.py
@@ -97,25 +97,25 @@ def test_nonexistent_path(all_parsers):
 
 @pytest.mark.skipif(WASM, reason="limited file system access on WASM")
 @td.skip_if_windows  # os.chmod does not work in windows
-def test_no_permission(all_parsers):
+def test_no_permission(all_parsers, temp_file):
     # GH 23784
     parser = all_parsers
 
     msg = r"\[Errno 13\]"
-    with tm.ensure_clean() as path:
-        os.chmod(path, 0)  # make file unreadable
+    path = temp_file
+    os.chmod(path, 0)  # make file unreadable
 
-        # verify that this process cannot open the file (not running as sudo)
-        try:
-            with open(path, encoding="utf-8"):
-                pass
-            pytest.skip("Running as sudo.")
-        except PermissionError:
+    # verify that this process cannot open the file (not running as sudo)
+    try:
+        with open(path, encoding="utf-8"):
             pass
+        pytest.skip("Running as sudo.")
+    except PermissionError:
+        pass
 
-        with pytest.raises(PermissionError, match=msg) as e:
-            parser.read_csv(path)
-        assert path == e.value.filename
+    with pytest.raises(PermissionError, match=msg) as e:
+        parser.read_csv(path)
+    assert path == e.value.filename
 
 
 @pytest.mark.parametrize(
@@ -269,19 +269,18 @@ def test_internal_eof_byte(all_parsers):
     tm.assert_frame_equal(result, expected)
 
 
-def test_internal_eof_byte_to_file(all_parsers):
+def test_internal_eof_byte_to_file(all_parsers, tmp_path):
     # see gh-16559
     parser = all_parsers
     data = b'c1,c2\r\n"test \x1a    test", test\r\n'
     expected = DataFrame([["test \x1a    test", " test"]], columns=["c1", "c2"])
-    path = f"__{uuid.uuid4()}__.csv"
+    path = tmp_path / f"__{uuid.uuid4()}__.csv"
 
-    with tm.ensure_clean(path) as path:
-        with open(path, "wb") as f:
-            f.write(data)
+    with open(path, "wb") as f:
+        f.write(data)
 
-        result = parser.read_csv(path)
-        tm.assert_frame_equal(result, expected)
+    result = parser.read_csv(path)
+    tm.assert_frame_equal(result, expected)
 
 
 def test_file_handle_string_io(all_parsers):
@@ -372,7 +371,7 @@ def test_read_csv_file_handle(all_parsers, io_class, encoding):
     assert not handle.closed
 
 
-def test_memory_map_compression(all_parsers, compression):
+def test_memory_map_compression(all_parsers, compression, temp_file):
     """
     Support memory map for compressed files.
 
@@ -381,16 +380,16 @@ def test_memory_map_compression(all_parsers, compression):
     parser = all_parsers
     expected = DataFrame({"a": [1], "b": [2]})
 
-    with tm.ensure_clean() as path:
-        expected.to_csv(path, index=False, compression=compression)
+    path = temp_file
+    expected.to_csv(path, index=False, compression=compression)
 
-        if parser.engine == "pyarrow":
-            msg = "The 'memory_map' option is not supported with the 'pyarrow' engine"
-            with pytest.raises(ValueError, match=msg):
-                parser.read_csv(path, memory_map=True, compression=compression)
-            return
+    if parser.engine == "pyarrow":
+        msg = "The 'memory_map' option is not supported with the 'pyarrow' engine"
+        with pytest.raises(ValueError, match=msg):
+            parser.read_csv(path, memory_map=True, compression=compression)
+        return
 
-        result = parser.read_csv(path, memory_map=True, compression=compression)
+    result = parser.read_csv(path, memory_map=True, compression=compression)
 
     tm.assert_frame_equal(
         result,
@@ -442,12 +441,11 @@ def test_context_manageri_user_provided(all_parsers, datapath):
 
 
 @skip_pyarrow  # ParserError: Empty CSV file
-def test_file_descriptor_leak(all_parsers):
+def test_file_descriptor_leak(all_parsers, temp_file):
     # GH 31488
     parser = all_parsers
-    with tm.ensure_clean() as path:
-        with pytest.raises(EmptyDataError, match="No columns to parse from file"):
-            parser.read_csv(path)
+    with pytest.raises(EmptyDataError, match="No columns to parse from file"):
+        parser.read_csv(temp_file)
 
 
 def test_memory_map(all_parsers, csv_dir_path):
diff --git a/pandas/tests/io/pytables/test_store.py b/pandas/tests/io/pytables/test_store.py
index 5cfefeb469e8a..8565c255ac067 100644
--- a/pandas/tests/io/pytables/test_store.py
+++ b/pandas/tests/io/pytables/test_store.py
@@ -41,22 +41,20 @@
 tables = pytest.importorskip("tables")
 
 
-def test_context(setup_path):
-    with tm.ensure_clean(setup_path) as path:
-        try:
-            with HDFStore(path) as tbl:
-                raise ValueError("blah")
-        except ValueError:
-            pass
-    with tm.ensure_clean(setup_path) as path:
-        with HDFStore(path) as tbl:
-            tbl["a"] = DataFrame(
-                1.1 * np.arange(120).reshape((30, 4)),
-                columns=Index(list("ABCD"), dtype=object),
-                index=Index([f"i-{i}" for i in range(30)], dtype=object),
-            )
-            assert len(tbl) == 1
-            assert type(tbl["a"]) == DataFrame
+def test_context(temp_file):
+    try:
+        with HDFStore(temp_file) as tbl:
+            raise ValueError("blah")
+    except ValueError:
+        pass
+    with HDFStore(temp_file) as tbl:
+        tbl["a"] = DataFrame(
+            1.1 * np.arange(120).reshape((30, 4)),
+            columns=Index(list("ABCD"), dtype=object),
+            index=Index([f"i-{i}" for i in range(30)], dtype=object),
+        )
+        assert len(tbl) == 1
+        assert type(tbl["a"]) == DataFrame
 
 
 def test_no_track_times(tmp_path, setup_path):
@@ -971,37 +969,36 @@ def test_pickle_path_localpath():
 
 
 @pytest.mark.parametrize("propindexes", [True, False])
-def test_copy(propindexes):
+def test_copy(propindexes, temp_file):
     df = DataFrame(
         1.1 * np.arange(120).reshape((30, 4)),
         columns=Index(list("ABCD")),
         index=Index([f"i-{i}" for i in range(30)]),
     )
 
-    with tm.ensure_clean() as path:
-        with HDFStore(path) as st:
-            st.append("df", df, data_columns=["A"])
-        with tempfile.NamedTemporaryFile() as new_f:
-            with HDFStore(path) as store:
-                with contextlib.closing(
-                    store.copy(new_f.name, keys=None, propindexes=propindexes)
-                ) as tstore:
-                    # check keys
-                    keys = store.keys()
-                    assert set(keys) == set(tstore.keys())
-                    # check indices & nrows
-                    for k in tstore.keys():
-                        if tstore.get_storer(k).is_table:
-                            new_t = tstore.get_storer(k)
-                            orig_t = store.get_storer(k)
-
-                            assert orig_t.nrows == new_t.nrows
-
-                            # check propindixes
-                            if propindexes:
-                                for a in orig_t.axes:
-                                    if a.is_indexed:
-                                        assert new_t[a.name].is_indexed
+    with HDFStore(temp_file) as st:
+        st.append("df", df, data_columns=["A"])
+    with tempfile.NamedTemporaryFile() as new_f:
+        with HDFStore(temp_file) as store:
+            with contextlib.closing(
+                store.copy(new_f.name, keys=None, propindexes=propindexes)
+            ) as tstore:
+                # check keys
+                keys = store.keys()
+                assert set(keys) == set(tstore.keys())
+                # check indices & nrows
+                for k in tstore.keys():
+                    if tstore.get_storer(k).is_table:
+                        new_t = tstore.get_storer(k)
+                        orig_t = store.get_storer(k)
+
+                        assert orig_t.nrows == new_t.nrows
+
+                        # check propindixes
+                        if propindexes:
+                            for a in orig_t.axes:
+                                if a.is_indexed:
+                                    assert new_t[a.name].is_indexed
 
 
 def test_duplicate_column_name(tmp_path, setup_path):
diff --git a/pandas/tests/io/test_common.py b/pandas/tests/io/test_common.py
index ab27fda8dcdf5..20b3103b74b9b 100644
--- a/pandas/tests/io/test_common.py
+++ b/pandas/tests/io/test_common.py
@@ -86,12 +86,11 @@ def test_stringify_path_fspath(self):
         result = icom.stringify_path(p)
         assert result == "foo/bar.csv"
 
-    def test_stringify_file_and_path_like(self):
+    def test_stringify_file_and_path_like(self, temp_file):
         # GH 38125: do not stringify file objects that are also path-like
         fsspec = pytest.importorskip("fsspec")
-        with tm.ensure_clean() as path:
-            with fsspec.open(f"file://{path}", mode="wb") as fsspec_obj:
-                assert fsspec_obj == icom.stringify_path(fsspec_obj)
+        with fsspec.open(f"file://{temp_file}", mode="wb") as fsspec_obj:
+            assert fsspec_obj == icom.stringify_path(fsspec_obj)
 
     @pytest.mark.parametrize("path_type", [str, CustomFSPath, Path])
     def test_infer_compression_from_path(self, compression_format, path_type):
@@ -338,49 +337,53 @@ def test_read_fspath_all(self, reader, module, path, datapath):
             ("to_stata", {"time_stamp": pd.to_datetime("2019-01-01 00:00")}, "os"),
         ],
     )
-    def test_write_fspath_all(self, writer_name, writer_kwargs, module):
+    def test_write_fspath_all(self, writer_name, writer_kwargs, module, tmp_path):
         if writer_name in ["to_latex"]:  # uses Styler implementation
             pytest.importorskip("jinja2")
-        p1 = tm.ensure_clean("string")
-        p2 = tm.ensure_clean("fspath")
+        p1 = tmp_path / "string"
+        p2 = tmp_path / "fspath"
         df = pd.DataFrame({"A": [1, 2]})
 
-        with p1 as string, p2 as fspath:
-            pytest.importorskip(module)
-            mypath = CustomFSPath(fspath)
-            writer = getattr(df, writer_name)
-
-            writer(string, **writer_kwargs)
-            writer(mypath, **writer_kwargs)
-            with open(string, "rb") as f_str, open(fspath, "rb") as f_path:
-                if writer_name == "to_excel":
-                    # binary representation of excel contains time creation
-                    # data that causes flaky CI failures
-                    result = pd.read_excel(f_str, **writer_kwargs)
-                    expected = pd.read_excel(f_path, **writer_kwargs)
-                    tm.assert_frame_equal(result, expected)
-                else:
-                    result = f_str.read()
-                    expected = f_path.read()
-                    assert result == expected
-
-    def test_write_fspath_hdf5(self):
+        string = str(p1)
+        fspath = str(p2)  # if hasattr(p2, '__fspath__') else p2
+
+        pytest.importorskip(module)
+        mypath = CustomFSPath(fspath)
+        writer = getattr(df, writer_name)
+
+        writer(string, **writer_kwargs)
+        writer(mypath, **writer_kwargs)
+        with open(string, "rb") as f_str, open(fspath, "rb") as f_path:
+            if writer_name == "to_excel":
+                # binary representation of excel contains time creation
+                # data that causes flaky CI failures
+                result = pd.read_excel(f_str, **writer_kwargs)
+                expected = pd.read_excel(f_path, **writer_kwargs)
+                tm.assert_frame_equal(result, expected)
+            else:
+                result = f_str.read()
+                expected = f_path.read()
+                assert result == expected
+
+    def test_write_fspath_hdf5(self, tmp_path):
         # Same test as write_fspath_all, except HDF5 files aren't
         # necessarily byte-for-byte identical for a given dataframe, so we'll
         # have to read and compare equality
         pytest.importorskip("tables")
 
         df = pd.DataFrame({"A": [1, 2]})
-        p1 = tm.ensure_clean("string")
-        p2 = tm.ensure_clean("fspath")
+        p1 = tmp_path / "string"
+        p2 = tmp_path / "fspath"
+
+        string = str(p1)
+        fspath = str(p2)
 
-        with p1 as string, p2 as fspath:
-            mypath = CustomFSPath(fspath)
-            df.to_hdf(mypath, key="bar")
-            df.to_hdf(string, key="bar")
+        mypath = CustomFSPath(fspath)
+        df.to_hdf(mypath, key="bar")
+        df.to_hdf(string, key="bar")
 
-            result = pd.read_hdf(fspath, key="bar")
-            expected = pd.read_hdf(string, key="bar")
+        result = pd.read_hdf(fspath, key="bar")
+        expected = pd.read_hdf(string, key="bar")
 
         tm.assert_frame_equal(result, expected)
 
@@ -432,35 +435,35 @@ def test_next(self, mmap_file):
                 with pytest.raises(StopIteration, match=r"^$"):
                     next(wrapper)
 
-    def test_unknown_engine(self):
-        with tm.ensure_clean() as path:
-            df = pd.DataFrame(
-                1.1 * np.arange(120).reshape((30, 4)),
-                columns=pd.Index(list("ABCD")),
-                index=pd.Index([f"i-{i}" for i in range(30)]),
-            )
-            df.to_csv(path)
-            with pytest.raises(ValueError, match="Unknown engine"):
-                pd.read_csv(path, engine="pyt")
-
-    def test_binary_mode(self):
+    def test_unknown_engine(self, temp_file):
+        path = temp_file
+        df = pd.DataFrame(
+            1.1 * np.arange(120).reshape((30, 4)),
+            columns=pd.Index(list("ABCD")),
+            index=pd.Index([f"i-{i}" for i in range(30)]),
+        )
+        df.to_csv(path)
+        with pytest.raises(ValueError, match="Unknown engine"):
+            pd.read_csv(path, engine="pyt")
+
+    def test_binary_mode(self, temp_file):
         """
         'encoding' shouldn't be passed to 'open' in binary mode.
 
         GH 35058
         """
-        with tm.ensure_clean() as path:
-            df = pd.DataFrame(
-                1.1 * np.arange(120).reshape((30, 4)),
-                columns=pd.Index(list("ABCD")),
-                index=pd.Index([f"i-{i}" for i in range(30)]),
-            )
-            df.to_csv(path, mode="w+b")
-            tm.assert_frame_equal(df, pd.read_csv(path, index_col=0))
+        path = temp_file
+        df = pd.DataFrame(
+            1.1 * np.arange(120).reshape((30, 4)),
+            columns=pd.Index(list("ABCD")),
+            index=pd.Index([f"i-{i}" for i in range(30)]),
+        )
+        df.to_csv(path, mode="w+b")
+        tm.assert_frame_equal(df, pd.read_csv(path, index_col=0))
 
     @pytest.mark.parametrize("encoding", ["utf-16", "utf-32"])
     @pytest.mark.parametrize("compression_", ["bz2", "xz"])
-    def test_warning_missing_utf_bom(self, encoding, compression_):
+    def test_warning_missing_utf_bom(self, encoding, compression_, temp_file):
         """
         bz2 and xz do not write the byte order mark (BOM) for utf-16/32.
 
@@ -473,17 +476,17 @@ def test_warning_missing_utf_bom(self, encoding, compression_):
             columns=pd.Index(list("ABCD")),
             index=pd.Index([f"i-{i}" for i in range(30)]),
         )
-        with tm.ensure_clean() as path:
-            with tm.assert_produces_warning(UnicodeWarning, match="byte order mark"):
-                df.to_csv(path, compression=compression_, encoding=encoding)
-
-            # reading should fail (otherwise we wouldn't need the warning)
-            msg = (
-                r"UTF-\d+ stream does not start with BOM|"
-                r"'utf-\d+' codec can't decode byte"
-            )
-            with pytest.raises(UnicodeError, match=msg):
-                pd.read_csv(path, compression=compression_, encoding=encoding)
+        path = temp_file
+        with tm.assert_produces_warning(UnicodeWarning, match="byte order mark"):
+            df.to_csv(path, compression=compression_, encoding=encoding)
+
+        # reading should fail (otherwise we wouldn't need the warning)
+        msg = (
+            r"UTF-\d+ stream does not start with BOM|"
+            r"'utf-\d+' codec can't decode byte"
+        )
+        with pytest.raises(UnicodeError, match=msg):
+            pd.read_csv(path, compression=compression_, encoding=encoding)
 
 
 def test_is_fsspec_url():
@@ -514,38 +517,39 @@ def test_is_fsspec_url_chained():
 
 
 @pytest.mark.parametrize("format", ["csv", "json"])
-def test_codecs_encoding(format):
+def test_codecs_encoding(format, temp_file):
     # GH39247
     expected = pd.DataFrame(
         1.1 * np.arange(120).reshape((30, 4)),
         columns=pd.Index(list("ABCD")),
         index=pd.Index([f"i-{i}" for i in range(30)]),
     )
-    with tm.ensure_clean() as path:
-        with open(path, mode="w", encoding="utf-8") as handle:
-            getattr(expected, f"to_{format}")(handle)
-        with open(path, encoding="utf-8") as handle:
-            if format == "csv":
-                df = pd.read_csv(handle, index_col=0)
-            else:
-                df = pd.read_json(handle)
+
+    path = temp_file
+    with open(path, mode="w", encoding="utf-8") as handle:
+        getattr(expected, f"to_{format}")(handle)
+    with open(path, encoding="utf-8") as handle:
+        if format == "csv":
+            df = pd.read_csv(handle, index_col=0)
+        else:
+            df = pd.read_json(handle)
     tm.assert_frame_equal(expected, df)
 
 
-def test_codecs_get_writer_reader():
+def test_codecs_get_writer_reader(temp_file):
     # GH39247
     expected = pd.DataFrame(
         1.1 * np.arange(120).reshape((30, 4)),
         columns=pd.Index(list("ABCD")),
         index=pd.Index([f"i-{i}" for i in range(30)]),
     )
-    with tm.ensure_clean() as path:
-        with open(path, "wb") as handle:
-            with codecs.getwriter("utf-8")(handle) as encoded:
-                expected.to_csv(encoded)
-        with open(path, "rb") as handle:
-            with codecs.getreader("utf-8")(handle) as encoded:
-                df = pd.read_csv(encoded, index_col=0)
+    path = temp_file
+    with open(path, "wb") as handle:
+        with codecs.getwriter("utf-8")(handle) as encoded:
+            expected.to_csv(encoded)
+    with open(path, "rb") as handle:
+        with codecs.getreader("utf-8")(handle) as encoded:
+            df = pd.read_csv(encoded, index_col=0)
     tm.assert_frame_equal(expected, df)
 
 
@@ -572,7 +576,7 @@ def test_explicit_encoding(io_class, mode, msg):
 
 @pytest.mark.parametrize("encoding_errors", ["strict", "replace"])
 @pytest.mark.parametrize("format", ["csv", "json"])
-def test_encoding_errors(encoding_errors, format):
+def test_encoding_errors(encoding_errors, format, temp_file):
     # GH39450
     msg = "'utf-8' codec can't decode byte"
     bad_encoding = b"\xe4"
@@ -591,18 +595,18 @@ def test_encoding_errors(encoding_errors, format):
             + b'"}}'
         )
         reader = partial(pd.read_json, orient="index")
-    with tm.ensure_clean() as path:
-        file = Path(path)
-        file.write_bytes(content)
+    path = temp_file
+    file = Path(path)
+    file.write_bytes(content)
 
-        if encoding_errors != "replace":
-            with pytest.raises(UnicodeDecodeError, match=msg):
-                reader(path, encoding_errors=encoding_errors)
-        else:
-            df = reader(path, encoding_errors=encoding_errors)
-            decoded = bad_encoding.decode(errors=encoding_errors)
-            expected = pd.DataFrame({decoded: [decoded]}, index=[decoded * 2])
-            tm.assert_frame_equal(df, expected)
+    if encoding_errors != "replace":
+        with pytest.raises(UnicodeDecodeError, match=msg):
+            reader(path, encoding_errors=encoding_errors)
+    else:
+        df = reader(path, encoding_errors=encoding_errors)
+        decoded = bad_encoding.decode(errors=encoding_errors)
+        expected = pd.DataFrame({decoded: [decoded]}, index=[decoded * 2])
+        tm.assert_frame_equal(df, expected)
 
 
 @pytest.mark.parametrize("encoding_errors", [0, None])
@@ -616,11 +620,10 @@ def test_encoding_errors_badtype(encoding_errors):
         reader(content)
 
 
-def test_bad_encdoing_errors():
+def test_bad_encdoing_errors(temp_file):
     # GH 39777
-    with tm.ensure_clean() as path:
-        with pytest.raises(LookupError, match="unknown error handler name"):
-            icom.get_handle(path, "w", errors="bad")
+    with pytest.raises(LookupError, match="unknown error handler name"):
+        icom.get_handle(temp_file, "w", errors="bad")
 
 
 @pytest.mark.skipif(WASM, reason="limited file system access on WASM")
diff --git a/pandas/tests/io/test_feather.py b/pandas/tests/io/test_feather.py
index 14643587465ea..4df716592e467 100644
--- a/pandas/tests/io/test_feather.py
+++ b/pandas/tests/io/test_feather.py
@@ -48,9 +48,10 @@ def check_round_trip(
         if expected is None:
             expected = df.copy()
 
-        to_feather(df, temp_file, **write_kwargs)
+        path = temp_file
+        to_feather(df, path, **write_kwargs)
 
-        result = read_feather(temp_file, **read_kwargs)
+        result = read_feather(path, **read_kwargs)
 
         tm.assert_frame_equal(result, expected)
 
@@ -229,15 +230,17 @@ def test_int_columns_and_index(self, temp_file):
         df = pd.DataFrame({"a": [1, 2, 3]}, index=pd.Index([3, 4, 5], name="test"))
         self.check_round_trip(df, temp_file)
 
-    def test_invalid_dtype_backend(self, temp_file):
+    def test_invalid_dtype_backend(self, tmp_path):
         msg = (
             "dtype_backend numpy is invalid, only 'numpy_nullable' and "
             "'pyarrow' are allowed."
         )
         df = pd.DataFrame({"int": list(range(1, 4))})
-        df.to_feather(temp_file)
+
+        path = tmp_path / "tmp.feather"
+        df.to_feather(path)
         with pytest.raises(ValueError, match=msg):
-            read_feather(temp_file, dtype_backend="numpy")
+            read_feather(path, dtype_backend="numpy")
 
     def test_string_inference(self, tmp_path, using_infer_string):
         # GH#54431